Welcome to PolarNet


Integrating genetic, biophysical and computational approaches
to understand cell and tissue polarity


Marie Skłodowska-Curie Actions Innovative Training Network 675407

We are excited to announce the PolarNet closing symposium “Principles of Polarity”, to be held at Utrecht University on the 13th of September 2019.

Polarnet has three objectives


PolarNet brings together academic and private partners from 7 European countries to establish a multidisciplinary training and research programme. Through individual research projects, 15 early stage researchers (ESRs) will study the basic principles of cell polarity.



Network-wide training events focused on cell polarity, biophysical and modelling approaches, transferable skills and personal development complement the high quality research training. Secondment opportunities ensure exposure to the private sector.


Outreach & Dissemination

PolarNet aims to inform the general public of its goals and activities through this website and outreach events organized by the ESRs and supervisors. Research results will be communicated in peer-reviewed scientific journals and at conferences.

The individual projects address three main research goals


Understanding how polarity emerges from interactions between individual components requires
mathematical modelling informed by experimentally determined parameters. Four research projects aim to better understand the fundamental principles that govern cell polarity.

Cortical polarity complexes

Mutual inhibitory interactions between protein complexes located at the cell cortex play a major role in cell polarity. Four research projects aim to obtain new insights into the roles of cortical polarity regulators in complex settings such as tissues or migrating cells.


In an organism, polarized cells rarely act in isolation, but are part of a larger tissue. Seven research projects study polarity in a multicellular context. Topics include integration of polarity and tissue mechanics, maintenance of tissue integrity, and use of new organoid models.


PolarNet Publication from University of Nice

Congratulations to PolarNet members Charles Puerner and Robert Arkowitz (University of Nice) for this beautiful paper! Using optogenetics they show how increased membrane localization of cdc42 in polarized cells resets growth and causes de novo clustering of secetory vesicles  https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30966-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719309660%3Fshowall%3Dtrue



My first GRC – an inspiring experience

I recently attended a Gordon Research Conference on Cell migration, in Galveston (Texas), 19 – 25 January 2019 , at a very beautiful location with the perfect weather. My first ever GRC – it was very exciting! The conference focused on the regulation of cell migration through the integration of biochemical signals, cytoskeletal alterations and […]



Robot check: 4 × = 8